Successful allogeneic stem cell transplantation with nonmyeloablative conditioning in patients with relapsed hematologic malignancy following autologous stem cell transplantation
نویسندگان
چکیده
منابع مشابه
Nonmyeloablative allogeneic hematopoietic stem cell transplantation.
Allogeneic hematopoietic stem cell transplantation (HSCT) is the most effective treatment for selected hematological malignancies. Its curative potential is largely mediated by an immune-mediated destruction of malignant cells by donor lymphocytes termed graft-versus-leukemia (GVL) effect. However, because of its toxicity, conventional allogeneic HSCT is restricted to younger and fitter patient...
متن کاملCMV infection following nonmyeloablative allogeneic stem cell transplantation using Campath.
We would like to comment on the recent report by Chakrabarti et al 1 on the risk of cytomegalovirus (CMV) infection following nonmyeloablative allogeneic transplantation. The conditioning regimen utilized by the authors consisted of fludarabine, melpha-lan, and a total dose of 100 mg of alemtuzumab (Campath-1H) given over 5 days. They found an 84.3% probability of CMV infection in patients at h...
متن کاملKinetics of engraftment in patients with hematologic malignancies given allogeneic hematopoietic cell transplantation after nonmyeloablative conditioning.
We analyzed the kinetics of donor engraftment among various peripheral blood cell subpopulations and their relationship to outcomes among 120 patients with hematologic malignancies given hematopoietic cell transplantation (HCT) after nonmyeloablative conditioning consisting of 2 Gy total body irradiation (TBI) with or without added fludarabine. While patients rapidly developed high degrees of d...
متن کاملReduced-intensity conditioning allogeneic stem cell transplantation in HIV patients with hematologic malignancies: yes, we can.
4 hours after the snake bite, when there has been ample time to exhaust endogenous clotting factors.3 Furthermore, the rate of recovery (based on INR) after antivenom treatment is expected to correlate with resynthesis of the consumed clotting factors. Notably, no reference was made to prothrombin levels after envenomation.3 We speculate that this information could provide greater insight into ...
متن کاملReduced-intensity conditioning allogeneic stem cell transplantation in pediatric patients.
PURPOSE/OBJECTIVES To determine if children undergoing reduced-intensity conditioning allogeneic hematopoietic stem cell transplantation (RIC-AlloHSCT) have lower incidence of acute toxicities and, subsequently, require less supportive care than is required with myeloablative conditioning (MAC)-AlloHSCT. An additional purpose is to examine later outcomes by comparing 100-day transplantation-rel...
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ژورنال
عنوان ژورنال: Biology of Blood and Marrow Transplantation
سال: 2001
ISSN: 1083-8791
DOI: 10.1053/bbmt.2001.v7.pm11760148